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Several Political Action Committees (PACs) and special interest groups have significant influence over US foreign policy, but it's important to note that their influence can vary depending on the specific policy issue and political context. Some of the most influential PACs and groups include:

1. American Israel Public Affairs Committee (AIPAC): AIPAC is one of the most powerful and influential PACs in the US, with a strong focus on US-Israel relations and Middle East policy.

2. National Rifle Association (NRA): While primarily focused on domestic gun rights, the NRA also has a significant presence in foreign policy debates, particularly regarding arms sales and military aid.

3. Lockheed Martin Corporation PAC: As a leading defense contractor, Lockheed Martin's PAC has significant influence over US defense and foreign policy, particularly regarding military spending and weapons sales.

4. Boeing Company PAC: Another major defense contractor, Boeing's PAC has substantial influence over US foreign policy, especially regarding defense contracts and international trade.

5. American Petroleum Institute (API) PAC: API represents the oil and gas industry and has significant influence over US energy policy, including foreign policy related to energy security and trade.

6. United States Chamber of Commerce PAC: The Chamber is a powerful business advocacy group with a broad range of interests, including international trade, commerce, and foreign policy.

7. Council for a Community of Democracies (CCD) PAC: CCD is a non-profit organization promoting democracy and human rights worldwide, with a PAC that supports candidates aligned with their mission.

8. Turkish Coalition USA PAC (TC-USA PAC): This PAC represents Turkish-American interests and has influence over US-Turkey relations and policy in the Middle East.

9. Saudi Arabia Lobby: Saudi Arabia has a significant lobbying presence in the US, with various PACs and firms representing Saudi interests, particularly regarding US-Saudi relations and Middle East policy.

10. China Lobby: China also has a substantial lobbying presence in the US, with various PACs and firms representing Chinese interests, particularly regarding US-China trade and diplomacy.