Yes, snake handling is wrong, because it is tempting God. When the devil tried to get Jesus to JUMP, (and JUMP is the key word,) off the pinnacale of the temple, he was trying to get Jesus to commit suicide. That's exactly what would have happened if Jesus had done it. Jesus was too smart for that. He used the word of God to defeat the devil. "It is written", He said, "Thou shalt not tempt the LORD thy God."
Snake handlers try to use
Mark 16:18 as the scriptural precept for that practice. "They shall take up serpents.", referring to believers. Some even try to make that a command. They make it a test of your faith. If you don't have the faith to pick up a poisonous serpent, or if you get bitten, then you aren't a true believer. Some groups are so extreme as to say you aren't even saved.
The only Bible example for handling snakes is in
Acts 28:3-6, where Paul was gathering sticks to make a fire after they had been shipwrecked on the island of Malta. Paul had
inadvertantly, ("inadvertantly" is the key word), picked up a viper, with the sticks.
The Bible is very clear: if you accidently, inadvertantly, or unknowingly, pick up a snake, fall from a height, or drink any deadly thing, then you have the right to expect the protective ministry of the angels to keep you from being harmed. (
Heb 1:13-14)